According to the fungal drug resistance and toxic adverse effect of antifungal drug, development of more effective and less toxic antifungal agents is the inevitable necessity of fungal treatment. Historically, plants have provided a source of inspiration for novel drug compounds, as plant derived medicines have made large contributions to human health and well being. This study was undertaken to evaluate the invitro effects of Ephedra major Host on fungi agent that are common cause of infections. Method: Four various Extracts from Ephedra major (collected from Alborz province, Iran) were assessed for antifungal activity against Trichophyton mentagrophytes (PTCC 5054), Microsporum canis (PTCC 5069), Candida albicans (ATCC 10231, PTCC 5027) and Nocardia asteroids (clinical isolated). The agar tubes containing known concentration of various extracts as well as extract free control, prepared and inoculated by microorganisms. Result: the methanol, ethanol and acetone extracts showed broad spectrum antifungal activity although aqueous extract was not able to fully inhibit fungal growth even at highest concentration 125 mg/ml. Conclusion: The ability of the Arial part extracts of E. major to inhibit the growth of Fungi is an indication of its broad spectrum antifungal potential which may be employed in the management of fungal infections or food preservation.
کلید واژگان :Ephedra major Host, Herbal extract, Antifungal, Phytomedicine
ارزش ریالی : 300000 ریال
با پرداخت الکترونیک