Biochemical and Hematological profile of Beta thalassemia major patients in Bushehr

Introduction Frequent infusion of blood in Beta thalassemia major can increase the iron load of the body which cause various complications with deposition in the liver, glands and other organs. The present study is the analysis of liver and kidney function, Hematological status, lipid patterns ,FBS and serum ions in beta-thalassemia major patients. Method This descriptive cross-sectional study which was done on all patients with beta thalassemia major in Bushehr city. The amounts of ALT, AST, ALP, Alb, Bili total, BUN, Cr, uric acid, TG, Cholestrol, LDL, HDL, FBS, Na, K, P, Ca, Hb, HCT, MCV, MCH, MCHC and ferritin were assessed. SPSS software v.16 were utilized for data analysis Result The statistical population included 106 patients (female: 59.5%, male: 40.5%) with an average age of 24.5±11.5 years old. serum ALT (39.52 U/L) and AST (42.24 U/L), ALP (371±176 U/L), Bili total (2.49±1/76 mg/dl), Bili Direct (0/58±0/20 mg/dl), FBS (123.77±71.79 mg/dl), P (5.35±0.87 mg/dl), Ca (9.9±0.63 mg/dl), TG (137±75 mg/dl ( were significantly higher in patients group in comparison to the control group. Lower serum Na (135.3±1.8 mmol/l), cholesterol (112.5±30.5 mg /dl), HDL (27±9.5 mg/dl), LDL (55±20.5 mg/dl), K (4.2±0.3 mmol/l) and Alb (4.64±0.3 g/dl) have been found in patients in comparison to the healthy group. The averages of Serum BUN, Cr and Uric acid were (14.85±6.26 mg/dl), (0.78±0.22 mg/dl) and (4.93±1.56 mg/dl) respectively. Hematological parameters as Hb (8.6±0.97 g/dl), HCT (27.1±2.6%), MCV (80±4.14 fl) and MCH (25.9±2.0 pg) have been significantly reduced in patients except MCHC (31.8±1.14 g/dl) and ferritin (3516±3087 ng/ml). Conclusion This study demonstrates that beta-thalassemia patients and healthy group have difference in serum contents of ions, liver function and biogenesis of lipids and lipoproteins is impaired.

Thalassemia major, Liver Enzymes, Ions, lipid patterns, Bushehr