Monoterpenes from the essential oils of several plants have been shown to enhance the bactericidal
activities of nitrofurantoin and furazolidone against the bacteria of Enterobacteriaceae family. In this
study, computer-aided molecular modeling and docking techniques have been employed to simulate
the theoretical mode of interaction between monoterpenes and Enterobacter cloacae nitroreductase.
Enhancement of nitro drug potency in the presence of monoterpenes may be the result of modulation
of nitroreductase activity. Binding nitroreductase with monoterpenes may decrease the efficient
conversion of toxic reactive intermediates to final products lacking bactericidal activity
