A series of furo[3,2-c]coumarin derivatives 1a–d were synthesized and evaluated for their antiproliferative
activity against MCF-7 breast and HCT-15 colon cancer cell lines using Sulfo-rhodamine B (SRB)
assay. Compounds 1b and 1d showed higher antiproliferative activity than 1a and 1c. UV–Vis spectroscopy
was used for DNA and BSA-binding affinity of the compounds 1b and 1d and gave overall affinity
constants of K
1b-DNA
= 8.1 10
3
M
1
, K
1d-DNA
= 1.1 10
4
M
1
, K
1b-BSA
= 5.1 10
4
=
7.6 10
4
M
1
. Our findings could provide new evidence showing the relationship between the chemical
structure and anticancer activity of these new coumarin analogs.
کلید واژگان :
coumarins, anticancer activity, antiproliferative activity , MCF-7 breast cancer
