An efficient method for synthesis of 2H-pyran-3,4-dicarboxylates using the three-component reaction of
dithiocarbamates, dialkyl acetylenedicarboxylates, and isocyanides in solvent-free conditions is described.
In these reactions, synthesis of dithiocarbamates is possibly based on the one-pot reaction of
secondary amines, CS
, and alkyl halides in solvent-free conditions without using a catalyst. The mild
reaction conditions and high yields of the reaction exhibit the good synthetic advantage of these
methods.
