Three-component synthesis of pyrano[2,3-d] pyrimidinone derivatives catalyzed by Ni2+ supported on hydroxyapatite-core–shell-c-Fe2O3 nanoparticles in aqueous medium

Pyrano[2,3-d]pyrimidine derivatives were synthesized via one-pot, threecomponent condensation reaction of aromatic aldehydes, malononitrile, and barbituric acid in aqueous ethanol catalyzed by Ni2? supported on hydroxyapatitecore– shell-c-Fe2O3 nanoparticles (c-Fe2O3@HAp-Ni2? NPs) as Lewis acid. The nontoxic nature and easy handling of the catalyst, environmentally friendly and facile work-up procedure, short reaction time, low catalyst loading, and high effectiveness to give products in good to excellent yield are advantages of this approach. Also, c-Fe2O3@HAp-Ni2? NPs can be easily recovered and reused for at least six runs.

Nanoparticles  Lewis acid catalyst  Supported Ni2?  Multicomponent reaction  Pyrano[2,3-d]pyrimidinone  Knoevenagel reaction