Summary Background: Tuberculosis is one of the most common infectious diseases
in the world. In recent years, genetically approach has been developed. One of the
interesting gene for investigator is IFN-gR1.
Aim: Determination of susceptibility to tuberculosis with polymorphism of IFN-gR1
gene.
Material and method: Study was prospective case–control. Fifty patients with smear
positive tuberculosis have been chosen randomly. They were matched with 54
healthy controls with no history of TB. Polymorphism at 395 codon of IFN-gR1 gene
was detected with Newport method. Data were analysed with SPSS version 11.
Results: Mean age of patients and control were 55G20 and 53G13.5 years,
respectively. Demographic characteristic had no difference within two groups. One
patient in case group had heterozygote mutation at IFN-gR1 gene. In control group
there were no mutations.
Conclusion: Genetically susceptibility to TB is not in 395 colon of IFN-gR1 in Iranian
TB sample and polymorphism of this loci has occur in 2% of TB patients and 0.96% of
total study population.
