Phenylephrine is used as a decongestant sold as an oral medicine, as a nasal spray, or as eye drops.
Phenylephrine is now the most common over-the-counter decongestant in the United States. In this
regard, measuring the solubility of phenylephrine hydrochloride seems applicable in supercritical carbon
dioxide-based processes dealing with this drug. The obtained solubility data obtained by a static method
coupled with gravimetric method were in the range of 1.01 × 10−4 to 2.89 × 10−3 based on the mole fraction
at the different temperature and pressure ranges of 308.15–338.15K and 160–400 bar, respectively.
In addition, the solubility data were used to obtain the adjusting parameters of semi-empirical correlations
namely Kumar and Johnston, Bartle et al., Chrastil and Mendez-Santiago-Teja using a simple data
regression.
