In the present work,the solubility of spironolactone in supercritical carbon dioxide was measured using a
static technique coupled with a gravimetricmethod. The solubility ofthismodel drug wasmeasured in the
ranges of 308–338K and 160–400 bar, respectively. The results showed that the solubility of spironolactone
was in the range of 6.25 × 10−5–5.01 × 10−3 based on the mole fraction at the studied temperatures
and pressures. In addition, the measured solubility data were correlated using semi-empirical density
based correlations (Mendez Santiago–Teja (MST) and Kumar and Johnston (K–J)) and an equation of state
(Peng–Robinson (PR)). Obtained results showed better capability ofthe semi-empirical correlations compared
with the PR-EoS for correlating the solubility of spironolactone at the studied temperatures and
pressures.
کلید واژگان :
Spironolactone Solubility Supercritical carbon dioxide Correlation Equation of state
