The enzyme rhodanese (thiosulfate: cyanide sulfurtransferase) is a ubiquitous enzyme and its activity is present in all living organisms. Many functions including cyanide detoxification, formation of iron-sulfur centers and participation in energy metabolism have been attributed to this enzyme. The enzyme catalyzes the transfer of a sulfur atom from sulfane containing compounds (such as thiosulfate) to thiophilic anions (such as cyanide). The sulfhydryl group of cysteine-247 in the molecule of rhodanese participates in a double displacement of sulfur transfer mechanism. In this review attempt will be made to summarize the latest information available on the molecular properties and the pattern of distribution of rhodanese in different tissues of domestic animals and to combine these different lines of research to arrive at a plausible explanation regarding the biological function of this important enzyme in living organisms.
کلید واژگان :Rhodanese, Active site, Distribution, Domestic animals, Cyanide detoxification
ارزش ریالی : 600000 ریال
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جزئیات مقاله
- کد شناسه : 1155013549628002
- سال انتشار : 2006
- نوع مقاله : پذیرفته شده در مجلات Scopus ,ISI با 4>IF>
- زبان : انگلیسی
- محل پذیرش : Iranian Journal of Veterinary Research, University of Shiraz, Vol. 7, No. 2, Ser. No. 15, 2006
- IF مجله :
- ISSN :
- تاریخ ثبت : 1397/11/25 12:41:36
- ثبت کننده : محمود امین لاری
- تعداد بازدید : 163
- تعداد فروش : 0