Zinc deficiency is one of the leading risk factors for developing disease and yet we do not have a clear understanding of the mechanisms behind the increased susceptibility to infection. A total of fourty male Wistar rats (120-160 g) were given zinc in the form of ZnSO4.6H2O at a dose level of 227 mg/L daily in their drinking water and diabetes was induced by giving a single subcutaneous injection of streptozotocin (40 mg/kg body weight). The Feed intake and body weight were recorded weekly. On day 56, blood was collected by retro-orbital puncture for analyzing hematological constituents, glucose, cholesterol, total protein, albumin, and globulin and antioxidant enzyme activities. At 57rd day, rats were antigenically challenged with sheep red blood cell to assay humoral immune response and cell-mediated immune response. The results showed that body weight and feed intake were not affected by dietary groups (P>0.05). The zinc supplementation had no effect on various hematological constituents analyzed. The serum cholesterol concentration was reduced by Zn supplementation group than the control group. In liver, TBARS and protein carbonyl concentration are indicative of oxidative stress significantly (p<0.05) lowered in Zn supplementation diet than the controls. The antioxidant enzyme activities (including GPx and CAT) were higher and MDA lowered for the animals fed Zn supplemented diet than the animals fed controls (P<0.05). The humoral and CMI response were higher (p<0.05) with Zn supplemented group than control group. The results showed that the inclusion of Zn supplementation in diabeticinduced rats diet caused to improved the antioxidant status
کلید واژگان :Diabetes; Rat; Immune System; Zn
ارزش ریالی : 300000 ریال
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