Study of Microscopic Effect of Palmatine on Diabetic Wound Healing of Male wistar Rats

Background: Diabetic foot is the most common cause for hospitalization among diabetic patients whose treatment is costly in the world. In developed countries, over 5% of diabetic patients are involved in diabetic foot, and if it is not treated quickly and appropriately . The aim of this study was investigating the effect of palmatine on wound healing of diabetic male wistar rats. Method: In this experimental study, 48 male Wistar rats with weight ranged between 180 and 240gr were selected and randomly divided into 4 groups of 12 animals. The Control group (healthy rats that received intraperitoneal citrate buffer along with induced diabetes of other groups), sham (streptozotocin induced diabetic rats with 55 mg/kg without treatment), first experimental (diabetic and treatment with eucerin) and second experimental (diabetic and treatment with palmatine). Wound healing process was investigated within 10 and 14 days after wounding using macroscopic and microscopic methods. Results: Wounds in the group that become diabetic with streptozotocin ( 10/87± 0.01) showed delayed healing compared to healthy group (2/56±0.001) and wound healing in the second experimental group with palmatine treatment (2/56±0.001) was accelerated compared to control group(0/5±0.001). Conclusion: The results showed that palmatein, which is twice daily, causes accelerated healing of skin lesions of healthy and diabetic specimens

Palmatine; Diabetic , Rat