A carbon paste electrode (CPE) was modified with
Pt-Co nanoparticles and 2-(3,4-
dihydroxyphenethyl)isoindoline-1,3-dione (3,4-DHPID) and
then used for determination of N-acetylcysteine (N-AC) in
the presence of paracetamol (PC) and folic acid (FA). The
Pt-Co nanoparticles were synthesized by the polyol method
and characterized by X-ray diffraction, energy dispersive Xray
analysis and transmission electron microscopy. The modified
CPE displays good electrocatalytic activity towards the
electrooxidation of N-AC in solution of pH 7.0. It was applied
to the determination of N-AC in the presence of PC and FA
(with well separated signals peaking at 0.2, 0.55 and 0.86 V
vs. Ag/AgCl) by using square wave voltammetry. The peak
currents are linearly dependent on the concentrations of NAC,
PC and FA in the respective ranges from 0.07 to 500,
1.0 to 850, and 2.0 to 550 μmol·L−1
, with detection limits of
0.009, 0.6 and 0.8 μmol·L−1
. The modified CPE was applied
to the determination of N-AC, PC and FA in (spiked) pharmaceutical
and biological samples.
