In this study, a carbon paste electrode (CPE) was
chemically modified with Pt/carbon nanotubes (CNTs) nanocomposite
and 8,9-dihydroxy-7-methyl-12H-benzothiazolo
[2,3-b] quinazolin-12-one (DMBQ). The synthesized nanocomposite
was characterized with different methods such as
transmission electron microscopy (TEM) and X-ray diffraction
(XRD). The modified electrode was used as an electrochemical
sensor for the determination of trace amounts of
N-acetylcysteine (N-AC). The propose sensor showed very
efficient electrocatalytic activity for the anodic oxidation of NAC,
owing to a substantial decrease in anodic overpotentials.
The peak current of square wave voltammograms (SWV) of
N-AC increased linearly with its concentration in the range of
0.1–600 μM. The detection limit was 0.07 μM at a signal-tonoise
ratio of 3, using squarewave voltammetry. The modified
electrode has been successfully applied for the assay of N-AC
in pharmaceutical and biological samples.
