An efficient, simple, and diastereoselective synthesis of novel benzofuran phosphonato esterderivativeshasbeenachievedviaaone-potthreecomponent reaction of euparin as a natural product, trialkyl phosphate, and dimethyl acetylenedicarboxylate (DMAD) in diethyl ether without using any catalystatroomtemperature.NMRspectroscopicdataand X-ray crystallography analysis are in agreement with the anti arrangement for the two vicinal protons in the structures, and only one diastereoisomer (2S,3R) or (2R,3S) was obtained for the products. The advantage of our research is that this is the first report for the diastereoselective synthesis of phosphonato ester derivatives from a green natural product. This one-pot reaction occurs in high yields with easy work-up under mild conditions. All pure products were obtained by recrystallization from ethanol, and there was no need for column chromatography
