Superparamagnetic Fe3O4 is shown to act as a very efficient catalyst for the one-pot, three-component
synthesis of a-aminonitriles from aldehydes, amines, and TMSCN. The catalyst is easily recovered by
the use of an external magnet and reused in several reactions without any noticeable loss of activity.
The products are obtained rapidly at room temperature in good purity upon separation of the catalyst
and evaporation of the volatiles of the reaction mixture.
