“β-CYCLODEXTRIN Nanoreactor” Catalyzed Synthesis of Coumarin Derivatives from In-Situ Generated Stabilized Phosphorus Ylides in Water

A convenient one-pot synthesis of coumarin derivatives from the three-component reaction of triphenylphosphine, an acetylenic ester and a phenol (1-naphthol, 2-naphthol and benzo[1,3]dioxol-5-ol) in the presence of a catalytic amount (4.5 mol%) of ß-cyclodextrin as a nanocatalyst and nanoreactor is reported. This methodology is of interest due to the use of water in the presence of this ß-cyclodextrin nanoreactor green reaction system.

phosphorus ylides, nanoreactor, nanocatalyst, phenol, dialkyl acetylenedicarboxylate, β-cyclodextrin.