Abstract Several reports indicate that Nigella sativa (N. sativa) have a beneficial effect on glycemic indices, so we performed a systematic review and meta-analysis of clinical trials to quantify the anti-hyperglycemic effect of N. sativa. An in-depth search to identify clinical trials investigating the impact of N. sativa on glycemic indices via MEDLINE, EMBASE and Google scholar databases was performed up to June 2017 with no limitation in time and language. We used a random effects model to estimate pooled effect size of fasting blood glucose (FBS), postprandial blood Glucose (PPBG), and hemoglobin A1C (HbA1C). A total of 16 RCTs investigating the effects of N. sativa on FBS, PPBG and HbA1C were included. Meta-analysis suggested a significant association between N. sativa supplementation and reduction in FBS (weighted-mean-difference [WMD]: -10.69 mg/dl, 95% CI: -14.45, -6.93), PPBG (WMD: -14.79 mg/dl, 95% CI: -24.19, -5.39), and HbA1C (WMD: -0.57%, 95% CI: -0.77%, -0.37). To sum up, N. sativa consumption have a significant lowering effect on glycemic control. Further studies with prolonged durations and powerful design are needed to specify the optimal dosage and duration of N. sativa supplementation to obtain a beneficial effect on glycemic control.
کلید واژگان :Nigella Sativa, Fasting Blood Sugar, Glycemic Control, Meta-Analysis
ارزش ریالی : 600000 ریال
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