اندازه گیری ترکیبات دارویی با استفاده از الکترود اصلاح شده با نانومواد

A sensitive and selective electrochemical method for the determination of cysteamine was developed using a ferrocene carboxaldehyde modified NiO nanoparticle carbon paste electrode (FCANiOCPE). The modified electrode exhibited good electrocatalytic activity for electrochemical oxidation of captopril at the pH of 7.0 phosphate buffer solution. The diffusion coefficient and the kinetic parameter such as the electron transfer coefficient of cysteamine at the surface of FCANiOCPE were determined using electrochemical approaches. Under the optimized conditions, the electrocatalytic oxidation peak current of cysteamine showed two linear dynamic ranges with a detection limit of 0.06 µmol L-1 cysteamine. The linear calibration ranges was in the range of 0.09-300.0 µmol L-1 cysteamine using square wave voltammetric method. Finally, this modified electrode was also examined for the determination of cysteamine in real samples such as drug and urine.