بررسي ارتباط بين ويسفاتين و فاكتورهاي التهابي سرم در افراد ديابتي آلوده به هليكوباكتر پيلوري در شهرستان تبريز

Introduction: Helicobacter pylori is one of the human pathogens that commonly affects the mucous membrane of the stomach and upper gastrointestinal tract and causes permanent inflammation in it. The prevalence of Helicobacter pylori infection in diabetic patients is reported to be associated with obesity andassociated metabolic disorders. In particular, the aim of this study is to find a logical relationship between H.Pylori infection in people with hyperglycemia syndrome with visfatin and inflammatory factors, including hs-CRP and serum myeloperoxidase enzymes. Materials and Method: This study was a case-control study. 58 subjects in case group were diabetic patients with gastrointestinal symptoms and infected with H.Pylori, and 58 subjects in control group who had diabetic subjects without gastrointestinal and non-infected symptoms were Helicobacter pylori. HbA1C measured by ion exchange chromatography, hs-CRP,visfatin, and myeloproxidase enzyme activity detected by ELISA method. The results were analyzed by SPSS software version 21. Results: The results of this study showed that HbA1C (p=0.012),hs-CRP(p=0.0001), visfatin (p=0.009)andthe activity of the myeloperoxidase enzyme activity(p=0.002).In the case group, the H.Pylori-infected diabetic patients had a significant increase compared to the control group. Conclusion: It seems that H.Pylori infection in diabetic patients causes severe hyperglycemia in the control of diabetes mellitus and more chronic inflammatory diseases than non-Helicobacter pylori diabetic patients. Keywords: H.Pylori, Diabetes, Visfatin, Inflammatory Factors