Simultaneous determination of 6-mercaptopruine,6-thioguanineand dasatinib as three important anti cancer drugs using nanostructure voltammetric sensor employing Pt/MWCNTs and1-butyl-3- methyl imidazolium hexa fluorophosphate

6-Mercaptopurine, 6-thioguanine and dasatinib are three important anticancer drugs with high adverse effects in human body. In this study, a Pt/MWCNTs-1-butyl-3-methylimidazolium hexa fl uoro phosphate- modi fi ed carbon paste electrode was developed for the simultaneously determination of 6-mercapto- purine, 6-thioguanine and dasatinib for the fi rst time. The Pt/MWCNTs synthesized by polyol method and have been characterized by transmission electron microscopy and X-ray diffraction methods. The ob- tained data revealed that the electro-oxidation of 6-mercaptopurine, 6-thioguanine and dasatinib is facilitated as a novel voltammetric sensor. After optimization of electrochemical parameters employing this sensor at pH 8.0, the oxidation peak currents for 6-mercaptopurine, 6-thioguanine and dasatinib were found to vary linearly with their concentrations in the range of 0.05 – 550 μ M; 0.1 – 500 μ M and 5.0 – 500 μ M with detection limits of 0.009 μ M, 0.05 μ M and 1.0 μ M respectively using square wave vol- tammetric method. The modi fi ed electrode has been applied for the selective and precise analysis of 6-mercaptopurine, 6-thioguanine and dasatinib in pharmaceutical formulations and urine samples.

6-Mercaptopurine 6-;Thioguanine; Dasatinib Sensor; Pt/MWCNTs; Ionic liquid