A novel nanomaterial-based voltammetric sensor has been developed for use a highly sensitive tool for the simultaneous
determination of captopril (CA), acetaminophen (AC), tyrosine (TY) and hydrochlorothiazide (HCTZ).
The device is based on the application of NiO/CNTs and (2-(3,4-dihydroxyphenethyl)isoindoline-1,3-dione)
(DPID) to modify carbon paste electrodes. The NiO/CNTs nanocomposite was synthesized through a direct chemical
precipitation approach and was characterized with X-ray powder diffraction (XRD), and scanning electron
microscopy (SEM). The NiO/CNTs/DPID/CPEs were found to facilitate the analysis of CA, AC, TY and HCTZ in
the concentration ranges of 0.07–200.0, 0.8–550.0, 5.0–750.0 and 10.0–600.0 μM with the respective detection
limits of 9.0 nM, 0.3 μM, 1.0 μMand 5.0 μM. The developed NiO/CNTs/DPID/CPEs were used for the determination
of the mentioned analytes in pharmaceutical and biological real samples.
