Total plasma leptin and adiponectin are regulated via chronic Exercise training in streptozocin-induced diabetic rats

The objective of the study was to determine the effects of exercise training on total plasma adiponectin and leptin concentrations in streptozocin-induced diabetic female rats. Thirty, eight week-old female Wistar rats (186 ± 12 g) were randomly assigned to two groups of healthy (n=12) and diabetic (n=18) induced by streptozocin injection, then healthy group were divided into two group of H1 and H2 as healthy control and diabetic group were split up into three groups of D1, D2 as diabetic control and Exe as a exercise training group. Before exercise protocol, samples were obtained from H1 and D1 groups. Exe group performed an 8-week exercise program on treadmill running (28 m/min ∼ %70-%75 VO2max) at 0◦ slope, 1 h/day, and 5 days/week. There were no significant differences induced by time between H1 and H2 group and D1 and D2 group in any variables. Total plasma adiponectin concentration were significantly higher in Exe compared with D2 (P<0.05), also plasma leptin concentration was higher in Exe (P<0.05) but HOMA-IR was not significantly different in Exe compared to D2. In Exe group blood glucose level was lower and insulin concentration was higher compared to D2 but the differences were not statistically significant. Thus, data suggest that 8 week exercise training with moderate intensity for 5 days per week may stimulate adiponectin synthesis and increase total plasma adiponectin concentrations in diabetic female rats.

adiponectin, leptin, exercise training, Insulin resistance