Comparing the Effect of Pentoxifylline Administration on Mast Cells Maturing Process in a Diabetic and Normoglycemic Rat Wound Healing

Background: Wound healing is a complicated process that is influenced by many factors. Studies at molecular level on human and animal models have revealed several molecular changes related to the effect of diabetes on wound healing process. Increasing number of researches implicates the influence of mast cells on skin wounds healing. The present experimental study was conducted to compare systemic pentoxifylline administration on maturing process of mast cells during skin wound healing in diabetic and normoglycemic rats. Materials and Methods: In this experimental study, 48 wistar rats were divided into 2 groups of normoglycemic and diabetic and each group was divided into experimental and control. Experimental group received intraperitoneal (25 mg/kg twice a day) and control group received distilled water. The number of mast cells and their maturing process was evaluated by microscopically counting of the types of mast cells (types 1, 2, 3) by stereological methods on day 3 and 7 after surgery. Results: In all experimental groups receiving pentoxifylline there were significant difference in the number of total mast cells, comparing normoglycemic groups (p<0.05) and also we found that in wound healing process pentoxifylline caused increasing the number of type 2 mast cells in all experimental groups (p<0.05). Conclusion: In all pentoxifylline treated groups delay in converting type 2 into type 3 mast cell was seen. Pentoxifylline causes decreasing mast cell degranulation during wound healing process.

Mast cell Pentoxifylline Rat Wound healing