Abstract: Background: The activity and role of different extracellular secreted enzymes has been
characterized in the pathogenesis of different fungal species. Phytase, a special class of histidine acid
phosphatases has recently been specified in some fungal species but not in Candida albicans. The objective
of the present study was to elucidate the ability of C. albicans strains from different sources to
secrete phytate and its correlation to pathogenicity.
Materials and Methods: A total of 100 C. albicans strains of which 25 isolated from patients with vulvovaginal
candidiasis (VVC), 25 from normal vagina, 25 from candiduria and 25 from buccal cavity
(healthy people) were included in the study. All strains were cultured on phytase specific agar medium. Phytase activity
was evaluated as phytase index (PI) according to visual method presented by Tsang using.
Results: Overall, 63 strains (63%) including all of the oral isolates, 88% of VVC and 64% of normal vagina isolates had a
high level of phytase activity (Phytase Index ≤ 0.50) while the remaining (37%) included all urinary tracts strains that
were unable to secrete phytase (0.50 Candida albicans, candidiasis, phytase
ارزش ریالی : 600000 ریال
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