Phytochemical investigation of the flowers of Anthemis odontostephana Boiss. var. odontostephana
(Asteraceae) resulted in the isolation of a natural cyclohexenone sesquiterpenoid with a bisabolene skeleton,
1-hydroxydelobanone (1), for the first time as a natural product, and a previously reported cyclohexenone
derivative, antheminone A (2), along with two known flavonoids, pectolinaringenin (3), and salvigenin (4).
The stereochemistry at positions C-4 and C-5 of the cyclohexenone ring of compound 2 was established
based on 1H–1H spin-spin coupling constants and ROESY spectra. Compounds 2 and 3 were reported
previously as antileishmanial and cytotoxic agents by other authors. The structures of the compounds were
elucidated using NMR spectroscopic methods including 1H NMR, 13C NMR, APT, COSY, HSQC, and HMBC,
and mass spectrometry.
کلید واژگان :
Anthemis odontostephana var. odontostephana, antheminone, sesquiterpenoid, cyclohexenone, salvigenin, pectolinaringenin.
