Glucose 6 phosphate dehydrogenase (G6PD) deficiency as an X-linked disorder is the most common human enzyme deficiency in the world. A Meta analysis regard G6PD deficiency showed its prevalence in Iran was between 2.1 to 7.6 percent. With regard to the fact that Iran is located in area with high prevalence of G6PD deficiency, and with respect to information that some other studies consider the role of hemolysis less important in the incidence of jaundice, therefore this cohort study was aimed to determine the relationship between hemolysis and G6PD enzyme deficiency by compare related data between 107 neonates suffering from jaundice having G6PD deficiency as experiment group, and the control group consisted of 127 neonates having normal G6PD enzyme activity. Result showed that the mean of bilirubin in the experiment group was 18.1 gram per deciliter, and 16.4 grams per deciliter in the control group (p=0.018). It can be concluded that there was no evidence of higher hemolysis among neonates suffering from jaundice having G6PD enzyme deficiency compared to neonates suffering from jaundice having normal G6PD enzyme activity. It also can be concluded that hemolysis is not an important factor in the incidence of jaundice in children having G6PD enzyme deficiency.
کلید واژگان :Hemolysis; neonate; Hyperbilirubinemia; G6PD deficiency
ارزش ریالی : 600000 ریال
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