Investigating the Effect of Imipramine Medication on Enzymes Changes of AST, ALT and ALK in Adult Female Rats

Introduction: Imipramine medication with the generic name of imipramine hydrochloride is a tricyclic antidepressant drug that has different side effects on different body systems. Since the use of this drug has become widespread and importance of liver enzymes and liver function, the main aim of the present study was to investigate the effect of imipramine medication on enzymes changes of AST, ALT and ALK in adult female rats. Methods and materials: Female Wistar rats were divided randomly into 5 groups. The first group (control group) did not receive any medication. The second group (sham) received only distilled water. Experimental group 1 received imipramine 6/25 mg/kg, the experimental group 2 received imipramine 12/5 mg/kg and experimental group 3 received imipramine 25 mg/kg intraperitoneally that was based on kilogram of body weight. At the end of day 30, the rats were bled and the serum concentrations of ALT, AST, and ALK were measured. Data were analyzed using SPSS version 18. Results: The results showed that the concentration of AST in the experimental groups 2 and 3 had significant increase compared to the control group. ALT concentration in experimental groups 1, 2 and 3 had significant increase compared to the control group. ALK concentration in experimental group 3 had significant increase compared to control group. Conclusion: The results showed that imipramine may increase liver enzymes and liver damage, so it should be taken with caution.

Imipramine, AST, ALT, ALK, Rat.