Introduction: Studies indicate that Artemisia extract caused a significant decrease in glucose levels in
diabetic animals. The aim of this study was to investigate the effect of Artemisia plant extracts to improve
diabetes complications and markers of liver damage, it is. Materials and Methods: 40 rats, adult female Wistar
rats randomized to the following groups for 56-day treatment groups (control, sham, diabetic (streptozotocin
55mg/ kg), diabetic + extract of Artemisia (200 and 300 mg/kg), diabetic + metformin 250 mg/kg control and
extract Artemisia (200 and 300 mg/kg). beginning and end of the experiment, body weight and blood glucose in
rats was measured, and then to measure ALT and AST of mice were bled after dissection, the liver removed and
fixed in 10% formalin and cutting and preparing for special studies were conducted respectively. Data editing
software spss statistics 15 and Duncan test were analyzed. The results indicate an increase in blood sugar,
necrosis, granulation and inflammatory lymphocytes in the liver and increased liver enzymes ALT and AST in
the diabetic group and decreased in the diabetic group treated are the groups received the extract of Artemisia
alone a significant increase in ALT levels was observed compared to controls (p ≤ 0.05). Conclusion: The
results of this study show that hydroalcoholic extract of Artemisia can significantly reduce the complications of
diabetes brought on liver but its use is not recommended for the average person that is because in some cases it
has harmful effects on consumers should receive careful consideration.
کلید واژگان :
Diabetes, Liver, Rat, Artemisia, histopathology, ALT and AST.
