A simple, efficient, eco-friendly, and cost-effective method has been developed for the synthesis of symmetrical
bisthioglycolic acid derivatives by a one-pot reaction of aldehydes or ketones with thioglycolic acid under solventand
catalyst-free conditions in excellent yields (87–97%). The advantages of this novel protocol include the
excellent yields, operational simplicity, short reaction times, and the avoidance of the use of organic solvents and
catalysts.
