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A general, facile, and efficient method is presented for the synthesis of 3-substituted 1,2,4-oxadiazoles from amidoximes and triethyl orthoformate. The procedure employs an iron(III) chloride/L-proline catalytic system and the 3-substituted 1,2,4-oxadiazole products are obtained in moderate to good yields.
کلید واژگان :1,2,4-oxadiazoles, iron(III) chloride, L-proline, amidoximes, triethyl orthoformate
ارزش ریالی : 600000 ریال
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