In this paper, spectral properties of Folic acid and Folinic acid as widely used drugs in the treatment of
some diseases have been studied in various environments with different polarity. Our results show that
the absorption, emission and stokes shifts of solute molecules depend strongly on molecular surrounding
characteristics, solute-solvent interactions and, different active groups in their chemical structures. In
order to investigate the contribution of specific and nonspecific interactions on various properties of drug
samples, the linear solvation energy relationships concept is used. Moreover, the calculated dipole
moments by means of solvatochromic method show that the high values of dipole moments in excited
state are due to local intramolecular charge transfer. Furthermore, the obtained results about molecular
interactions can be extended to biological systems and can indicate completely the behaviors of Folic acid
and Folinic acid in polar solvents such as water in body system
کلید واژگان :
Folic acid Folinic acid Local intramolecular charge transfer Linear salvation energy relationship Dipole moment
