Absorption and emission spectra of three antitumour anthracyclines, with various substituent and
stereoisomer groups, were studied in different solvents. The solute’s photo-physical behavior strongly
depends on solvent–solute interactions and solvent’s nature. Solvatochromic method was used to investigate
dipole moments of these materials in ground and excited states. Spectral variations were analyzed
via means of linear solvation energy relationships concept, proposed by Kamlet and Taft. The results
explain the nature of specific and non-specific solvent–solute interactions and functional groups’
reorientation of studied anthracyclines in different media.
کلید واژگان :
Anthracycline Stereoisomer Linear solvation energy relationship Solvent polarity scale Dipole moment Intramolecular hydrogen bonding
