Since the knowledge of pharmaceutical solubilities in the supercritical carbon dioxide is one of
the first essential necessities for designing the supercritical carbon dioxide-based processes,
solubility of piroxicam a non-steroidal anti-inflammatory drug was experimentally measured. In
this regard, a static method coupled with gravimetric method was used to measure the solubility
of piroxicam in the supercritical carbon dioxide in temperature and pressure range of 308.15 K to
338.15 K and 16 MPa to 40 MPa, respectively. The obtained solubility data were in the range of
1.17×10-5 and 5.12×10-4 based on the mole fraction (mole piroxicam/ (mole piroxicam + mole
CO2)) then modeled using four different density based correlations namely Bartle et al., Mendez-
Santiago-Teja, Chrastil and Kumar and Johnston models. The results of error analysis revealed
that the used correlations were potential to correlate the solubility of piroxicam with minimum
and maximum average absolute relative deviation percents (AARD %) of 14.4 % and 15.2 %,
respectively.
