Evaluation of Lipid Profiles Serum in Subjects Infected and Non-Infected with Helicobacter Pylori

Aims: Helicobacter pylori infection is one of the most important factors of peptic ulcer and other gastrointestinal disorders. Gastritis caused by H. pylori infection has a high prevalence and about 10 percent of people in their lifetime will suffer from gastritis. Some studies have shown an association between H. pylori and atherosclerosis that may exist. The results of studies showed that the presence of H. pylori in peptic ulcer gut leads to changes in lipid profile including cholesterol, triglycerides and lipoproteins are HDL-c and LDL-c. The purpose of this study was to evaluate the serum lipid profile and inflammatory factors in individual’s infected and non-infected with H. pylori. The measurement levels of lipids profiles and inflammatory factors in patients with H. pylori infection as cases of atherosclerosis and heart disease rate would be very useful vessel. Materials and Methods: In this study 58 patients with active peptic ulcer and positive rapid urease test (22 female & 36 male) referring to gastroenterology clinic with mean age of 45.30±13.16 as case group and 58 patients without active peptic ulcer and negative rapid urease test (20 female & 38 male) with mean age of 42.67±16.04 were selected as control group. Two groups of patients were selected we took one blood sample and two gastric biopsy specimens. Biopsy specimens to confirm the absence of infected or non-infected with H. pylori has been sent to the pathology laboratory. Blood samples for measurement of serum lipid profile in use. Total cholesterol, triacylglycerol, HDL- cholesterol, LDL- cholesterol, was measured. Results: In the case group rate of serum lipid profiles, including total cholesterol, triacylglycerol, LDL and HDL compared with the control group are statistically significant and increased (In all p<0.0001). Discussion: Because heart disease burden on health and economic society entered the building. According to the results of this study and other studies certainly can be said that H. pylori infection have increased levels of lipid profile. The increase of this factors the risk of causing a very high potential in cardiovascular diseases and atherosclerosis.

Helicobacter pylori infection, cardiovascular risk factor, lipid profile and atherosclerosis