Novelamphiphilicstar-shapedterpolymerscomprisedofhydrophobicpoly( 휺 -caprolactone),pH-sensitivepolyaminoesterblock and hydrophilic poly(ethylene glycol) ( M n = 1100, 2000 g mol − 1 ) were synthesized using symmetric pentaerythritol as the core initiator for ring-opening polymerization (ROP) reaction of 휺 -caprolactone functionalized with amino ester dendrimer structure at all chain ends. Subsequently, a second ROP reaction was performed by means of four-arm star-shaped poly( 휺 -caprolactone) macromer with eight -OH end groups as the macro-initiator followed by the attachment of a poly(ethylene glycol) block at the end of each chain via a macromolecular coupling reaction. The molecular structures were verified using Fourier transform infrared and 1 H NMR spectroscopies and gel permeation chromatography. The terpolymers easily formed core–shell structural nanoparticles as micelles in aqueous solution which enhanced drug solubility. The hydrodynamic diameter of these agglomerates was found to be 91–104 nm, as measured using dynamic light scattering. The hydrophobic anticancer drug curcumin was loaded effectively into the polymeric micelles. The drug-loaded nanoparticles were characterized for drug loading content, encapsulation efficiency, drug–polymer interaction and in vitro drug release profiles. Drug release studies showed an initial burst followed by a sustained release of the entrapped drug over a period of 7days at pH = 7.4 and 5.5. The release behaviours from the obtained drug-loaded nanoparticles indicated that the rate of drug release could be effectively controlled by pH value. Altogether, these results demonstrate that the designed nanoparticles have great potential as hydrophobic drug delivery carriers for cancer therap
کلید واژگان :star polymer; poly(
ارزش ریالی : 600000 ریال
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