The ionic complexation of different chemical compositions of alginate and its sulfated derivative with tetracycline hydrochloride (TCH), as a cationic drug model, was investigated. The complexes of TCH with mannuronate-enriched alginate entrapped the highest amount of the drug. However, the ability of all un-modified alginates for ionic complexation was very weak. Interestingly, the chemical modification of alginate with sulfate groups resulted in drug-polymer complexes with remarkable entrapment efficiency of TCH. The results of this study suggested alginate sulfate as a promising biomaterial in designing delivery systems for cationic small molecule drugs.
کلید واژگان :
Polymer; Biomaterials; Chemical composition; Sulfated modification; Ionic complex
