The agglutinin-like sequence (ALS) gene is the largest gene family among known adhesions in Candida albicans. It is known that ALS family members interact with several substrates, including host cells and proteins. ALS family plays a role in the biofilm formation which is responsible for not only many chronic microbial infections but infections based on medical devices. The N-terminal part of ALS proteins constitutes the substrate-specific binding domain and is responsible for attachment to epithelial and endothelial cells. Homology modeling is currently the most accurate method to generate reliable three-dimensional protein structure models and is routinely used in many practical applications. In this study the N-terminal parts of ALS proteins were modeled. The results showed that the N-terminal site of ALS proteins’ structures consist of two beta sheet connected by an alpha helix that constitute βαβ motif.
کلید واژگان :agglutinin like sequence protein 1, Candida albicans; biofilm; infection; modeling.
ارزش ریالی : 500000 ریال
با پرداخت الکترونیک