Highly efficient and eco-friendly protocol for the synthesis of bis(3-indolyl)methanes by the
electrophilic substitution reaction of indole with aldehydes catalyzed by Fe3O4@SiO2-imid-PMAn was
described. Simple work-up procedure, shorter reaction times, excellent yields, avoiding hazardous
organic solvents, and reusability of the catalyst are the most obvious advantages of this method. Also,
the catalyst can be easily recovered by a magnetic field and reused for six consecutive reaction cycles
without significant loss of activity.
کلید واژگان :
Bis(indolyl)methanes; Indole, Aldehydes, Green synthesis, Multi-component reactions, Magnetic nanoparticles, Magnetic separation.
