Long non-coding transcripts, in leukemia: What do we know about them?

Over past years, non-coding RNAs(ncRNAs) have been strongly attracting researchers and clinicians attention. Some of the most important types of ncRNAs are long non-coding RNAs(lncRNAs). It’s been proofed that they play a major role in cancers and especially leukemia. Several reports have identified specific patterns of lncRNA expression associated with human leukemia. They could have a potential impact on diagnosis, prognosis, screening/follow-up and classification of hematologic malignancies. Recent findings have revealed lncRNAs as diagnostic or prognostic biomarker, novel drug targets or even as a cause of therapy resistance due to their significate role in gene regulation, epigenetic control and regulation of RNA processing such as splicing, editing, translation, turn-over/degradation and many known and unknown functions that’s adding an additional layer of complexity in human leukemia.

ncRNAs ,long non-coding RNAs(lncRNAs), leukemia,