A review on the role of parasite infection in multiple sclerosis and recommendation of Olibanum as a new herbal treatment

Background: Multiple sclerosis is a common neurological disease of humans especially women. Helminths have been shown to augment immunoregulation so it can be used to MS treatment such as recent researches with Trichuris suis eggs in MS revealed good tolerance and surprising clinical effects. It can be used to Olibanum as one herbal treatment, orally beside parasite treatment, too. Materials and Methods: In this study, which is a systematic review study, all papers presented on this subject were evaluated at the databases, SID, Google Scholar, PubMed, Scopus, and others. In the last 50 years, environmental factors such as helminth infections have been proposed to explain why autoimmunity is less prevalent in the developing world; this proposal has been termed the hygiene or old friend's hypothesis. Results and conclusion: It is widely accepted that the Th2 and Treg cell responses which develop in helminth infections can suppress autoimmune disease such as MS. Recent researches with Trichuris suis eggs in MS revealed good tolerance and surprising clinical effects. The mechanism of protection is manifold and included; the increasing activity of T reg cell, activated macrophage, inducing Th2 related cytokines with antiinflammatory qualities and more recently, IL-10 producing regulatory B cells. Trichuris suis has the potential as an effective, safe and orally available treatment option in MS. Also, MS disease is a type of autoimmune disease in which the immune system considered the spinal cord myelin as a foreign agent and destroys it, and on the other hand, given the growing global acceptance of the use of medical plants, which is due to the modification of the immune system of the person on one side, as well as the ability to decontaminate bacterial and viral causes. With this herbal treatment, we can be hoped that MS will be eradicated forever soon, as we are currently researching mouse as a laboratory model for humans, which will be published, as soon as possible

Parasite infection, MS, Olibanum, Herbal treatment.