Background. Diabetic foot infections (DFIs) are a major public health issue and identification of the microorganisms causing
such polymicrobial infections is useful to find out appropriate antibiotic therapy. Meanwhile, many reports have shown antibiotic
resistance rising dramatically. In the present study, we sought to determine the prevalence of microorganisms detected on culture in
complicated DFIs in hospitalized patients and their antibiotic sensitivity profiles. Methods. A cross-sectional study was conducted
for a period of 24 months from2012 to 2014 inNemazeeHospital, Shiraz, Iran.The demographic and clinical features of the patients
were obtained. Antimicrobial susceptibility testing to different agents was carried out using the disc diffusion method. Results.
During this period, 122 aerobic microorganisms were isolated from DFIs. Among Gram-positive and Gram-negative bacteria,
Staphylococcus spp. and E. coliwere themost frequent organisms isolated, respectively.Of the isolates,91%weremultidrugwhile 78%
of S. aureus isolates were methicillin resistant. 53% of Gram-negative bacteria were positive for extended-spectrum
