Background and Aim: Widespread multidrug-resistant Acinetobacter baumannii (MDR-AB) strains have limited therapeutic options for treating intensive care unit (ICU) patients with MDR-AB infection in Iran. We aimed to evaluate MDR-AB diversity and antimicrobial susceptibility in Tehran (Iran) to address the need for feasible and effective control approaches against severe MDR-AB infections. Methods: We used amplified fragment length polymorphism (AFLP) and minimum inhibitory concentration (MIC) determinations to compare genotypic diversity and susceptibility patterns of 100 MDR-AB isolates from ICU patients in two medical centers in Tehran (Iran), from 2006 to 2011. Results: Within 5 years, drastic genotypic changes occurred among MDR-AB isolates, and resistance to antimicrobials increased 0–30%. In 2011, 6–100% of isolates were resistant to every agent tested. All isolates remained susceptible to either minocycline or tobramycin, however, MIC50 concentrations against these agents increased. Novel international clone (IC) variants (not IC I–III types) comprised 36% MDRAB isolates in 2011. Conclusions: The MDR-AB population in Tehran is rapidly changing toward growing resistance to various antimicrobials, including colistin and tigecycline. Although increasing resistance to lastresort antimicrobials is alarming, simultaneous susceptibility of all MDR-AB isolates to some conventional antibiotics highlights the merits of investigating their synergistic activity against extended-spectrum and pandrug resistant A. baumannii. Integrating the novel Iranian MDR-AB IC variants into epidemiologic clonal and susceptibility profile databases can help global efforts toward the control of MDR-AB pandemic
کلید واژگان :Acinetobacter baumannii, Genotypic Profile
ارزش ریالی : 600000 ریال
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