Efficient One-Pot Synthesis of Some New Xanthene Derivatives Based on the Reaction of Dimedone with α,α′-Bis(substituted-benzylidene) Cycloalkanones Using Catalytic Amount of pTSA

A one-pot synthesis of a series of new xanthene derivatives has been achieved for the first time based on an application of Michael reaction between dimedone (5,5-dimethylcyclohexan-1,3-dione) and a,a ’-bis(substituted-benzylidene)cycloalkanones using catalytic amount of p-toluene sulfonic acid as catalyst. The xanthenes were achieved efficiently via intramolecular cyclization of the Michael adduct.

a,a0-Bis(substituted-benzylidene)cycloalkanones; dimedone; Michael addition; p-toluenesulfonic acid; xanthenes