Process parameters optimization for tissue engineered chitosan/gelatin nanofibrous scaffolds

In this study, nanofibers were electrospun from chitosan and gelatin at several blends (chitosan/gelatin: 80/20, 60/40, 50/50, 40/60, 20/80) with different processing parameters (voltage, flow rate and distance between the tip of the needle and collector). Fo transform infrared (FTIR), scanning electron microscopy (SEM), for biomedical applications. The samples with 20% chitosan and 80% gelatin under special processing conditions (flow rate: 0.1 voltage: 12 kV and distance: 16 cm) had the least amount of droplets and beads. Tensile mechanical test showed that the cross nanofiber scaffold with 20% chitosan and 80% gelatin is the best choice when mechanical properties are required. In a crosslinked scaffolds with 20% chitosan and 80% gelatin and 50% chitosan and 50% gelatin had the least and most amoun degradation respectively.

Nanomaterials, Electrospinning, Tissue engineering, Chitosan, Gelatin