Modeling the effect of autoreactive T-cells on oligodenderocytes in multiple sclerosis patients using chitosan/gelatin nanofibrous scaffolds

In this study, nanofiberous scaffolds were fabricated from chitosan and gelatin at different blends (chitosan/gelatin: 80/20, 20/80) using electrospinning. Scanning electron microscopy (SEM), contact angle test, porosity measurement, and scaffold biocompatibility through PC-12 cells were used to evaluate scaffolds for tissue engineering applications. Nanofibers with 50% chito and 50% gelatin were the ideal option for neural tissue engineering. Thereafter, T sclerosis (MS) patients and healthy controls. In addition, the assessments of the effects of MS patients’ T and morphology were carried out onto optimal fabricated nano performed for the evaluation of B7-1(CD80), B7 molecules in OLN-93 cells increased as expected. Also, the finding can be used for future studies on MS treatment.

Neural tissue engineering, multiple sclerosis, nanofibers, chitosan, gelatin