In this study, rapid expansion of supercritical solution with supercritical carbon dioxide as a
solvent is used to micronize fenoprofen particles. Effects of different operating parameters were
discussed by the method of changing one factor at a time for the extraction temperature
(313–333 K), extraction pressure (140–220 bar), collection distance (1–10 cm), nozzle length
(2–15 mm), and effective nozzle diameter (450–1700 lm) on the size and morphology of the
fenoprofen particles. The conducted experiments revealed that not only the fenoprofen particles
were micronized from 24.3 lm to the range of 10.6 lm and 3.3 lm but also the fenoprofen
particles experience a modification on their morphologies.
