Bile salts are ionic amphiphilic compounds with a steroid skeleton. Among the most important physiological properties of bile salts are lipid transport by solubilization and transport of some drugs through hydrophobic barriers. Bile salts have been extensively studied to enhance transepithelial permeabilityfor different marker molecules and drugs. They readily agglomerate at concentrations above their criticalmicelle concentration (CMC). The mechanism of absorption enhancement by bilesalts appears to be complex. The aim of the present article was toreview bile salt structure and their application as absorption enhancers and the probable mechanism for increasing permeation based on previous studies.
کلید واژگان :bile salts; drug delivery; absorption enhancers
ارزش ریالی : 300000 ریال
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