Aim: Prostate cancer is one of the most frequent cancers in men and it is reported that about one in nine men experience the disease in their lifetime. It has been found that in some cases, HPV can be a culprit for prostate cancer. The present meta-analysis study aims to examine whether human papillomavirus (HPV) serves as a foundation of human prostate cancer. Methods: Related studies to HPV and prostate cancer from 1990 to 2020 were sought in PubMed and Google Scholar. Earlier published expert reviews and systematic meta-analysis were utilized as a supplementary source to recognize appropriate articles. Finally, data from 54 articles, with 7072 prostate cancer cases, were pooled and analyzed. Results: The pooled rating for the odds ratio was 17.42%. Stratified pooled analyses were subsequently performed according to the HPV detection of geographical regions, publication years, the number of prostate cases, and HPV-positive cases. Conclusion: The meta-analysis confirmed the variant frequencies of HPV positivity in prostate cancer of different geographic zones. It has been found that there can be a potential link between HPV and prostate cancer. Yet, further investigations of this cancer relating to HPV may be necessary.
کلید واژگان :human papillomavirus , meta-analysis , prostate cancer , risk factor
ارزش ریالی : 600000 ریال
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