Onosma microcarpum (Boraginaceae) locally known as “Tashnedary” is
considered as one of important medicinal plants in west of Iran. Its roots have
been used by the rural healers to treat the burns and wound healing.
In this study, different extracts of roots were used for the evaluation of its
healing effect in diabetic wound model in rats. Diabetes was induced in Wistar
rats, then wound incised on the back of rat, and subsequently they were
divided into nine groups which eight of them contain eucerin with four
concentrations of hexane extract (20%, 30%, 40%, 60%) and three other
extract as aceton30%, ethanol30% and hydroEthanol30%, and one base
eucerin without extract. Other formula was traditional formula and phenytoin.
A photograph of the dorsum of the rat was taken from a standard height in
days 0, 3, 6, 9, 15 and 20. Then, samples were processed in the pathologic
surveys. Our study showed that the best result was demonstrated by
Phenytoin cream treated group.
Our results indicated that like the general belief in west of Iran population, the
ointment with n-Hex30% extracts of O. microcarpum could promote healing in
described animal model, diabetic foot ulcer, compared to control.
